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pentobarbital will lessen the extent or effect of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Strong or average CYP3A inducers may perhaps lessen cobimetinib systemic exposure by >eighty% and lower its efficacy.pentobarbital will reduce the level or impact of atazanavir by impacti